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中药化学

刘友平

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个人简介

刘友平,女,研究员,中共党员。中药学博士、博士后,博、硕士研究生导师,享受国务院政府特殊津贴,四川省学术技术带头人、四川省有突出贡献的优秀专家、四川省专家服务团专家、全国老中医药专家学术经验继承人,四川省中医药产业推进工作先进个人。国家自然科学基金同行评议专家,国家药品监督管理局保健食品审评专家,四川省科技项目评审专家,四川省科学技术奖评审专家。

长期从事中药化学、中药品质评价、中药药效物质基础与质量标准化研究,主持完成国家自然科学基金、国家中医药管理局、国家标准化委员会行业科研专项、国家药典委会中药标准提高项目、四川省重点研发项目等国家级、部省级科研项目(课题)10余项,有较强的科学研究组织、实施能力。发表学术论文200余篇(SCI/中文核心期刊),获国家发明授权专利16件;获四川省科技进步二等奖5项(1项主持)、三等奖3项(1项主持),培养博、硕士研究生90余名。


代表性成果

1.期刊论文

(1) Wang Z, Xu G, Wang H, Zhan X, Gao Y, Chen N, Li R, Song X, Guo Y, Yang R, Niu M, Wang J, Liu Y, Xiao X, Bai Z. Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation. Acta Pharm Sin B. 2020 Sep;10(9):1619-1633.(IF:14.9)

(2) Wang Z, Xu G, Gao Y, Zhan X, Qin N, Fu S, Li R, Niu M, Wang J, Liu Y, Xiao X, Bai Z. Erratum: Author correction to 'Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome' [Acta Pharmaceutica Sinica B 9 (2019) 734-744]. Acta Pharm Sin B. 2020 Dec;10(12):2433-2434.(IF:14.9)

(3) Wang Z, Xu G, Gao Y, Zhan X, Qin N, Fu S, Li R, Niu M, Wang J, Liu Y*, Xiao X*, Bai Z*. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome. Acta Pharm Sin B. 2019 Jul;9(4):734-744.(IF:14.9)

(4) Ding H, You Q, Li D, Liu YP*. 5-Demethylnobiletin: Insights into its pharmacological activity, mechanisms, pharmacokinetics and toxicity. Phytomedicine. 2022 Sep;104:154285.(IF:6.66)

(5) Zhang L, Niu M, Wei AW, Tang JF, Li PY, Song D, Bai ZF, Liu YP*, Xiao XH, Wang JB. Correction: Clinical correlation between serum cytokines and the susceptibility to Polygonum multiflorum-induced liver injury and an experimental study. Food Funct. 2022 Dec 13;13(24):13064.(IF:6.32)

(6) Zhang L, Niu M, Wei AW, Tang JF, Li PY, Song D, Bai ZF, Liu YP*, Xiao XH, Wang JB. Clinical correlation between serum cytokines and the susceptibility to Polygonum multiflorum-induced liver injury and an experimental study. Food Funct. 2022 Jan 24;13(2):825-833.(IF:6.32)

(7) Zhang L, Niu M, Wei AW, Tang JF, Tu C, Bai ZF, Zou ZS, Xiao XH, Liu YP, Wang JB. Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multifloIcariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation. rum. Arch Toxicol. 2020 Jan;94(1):245-256.(IF:6.17)

(8) Zhang L, Niu M, Wei AW, Tang JF, Tu C, Bai ZF, Zou ZS, Xiao XH*, Liu YP*, Wang JB*. Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum. Arch Toxicol. 2020 Jan;94(1):245-256.(IF:6.17)

(9) Wang Z, Xu G, Zhan X, Liu Y, Gao Y, Chen N, Guo Y, Li R, He T, Song X, Niu M, Wang J, Bai Z*, Xiao X*. Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice. Arch Toxicol. 2019 Dec;93(12):3585-3599.(IF:6.17)

(10) Yang F, He L, Shen M, Wang F, Chen H, Liu YP*. A Correlation Between Pericarpium Citri Reticulatae Volatile Components and the Change of the Coexisting Microbial Population Structure Caused by Environmental Factors During Aging. Front Microbiol. 2022 Jul 22;13:930845.(IF:6.06)

(11) You Q, Li D, Ding H, Chen H, Hu Y, Liu Y*. Pharmacokinetics and Metabolites of 12 Bioactive Polymethoxyflavones in Rat Plasma. J Agric Food Chem. 2021 Nov 3;69(43):12705-12716. doi: 10.1021/acs.jafc.1c05004. Epub 2021 Oct 26. PMID: 34699208.(IF:5.90)

(12) You Q, Li L, Li D, Yang D, Chen L, Chen HP, Liu YP. Meta-Analysis on the Chinese Herbal Formula Xiaoer-Feike Granules as a Complementary Therapy for Children With Acute Lower Respiratory Infections. Front Pharmacol. 2020 Oct 22;11:496348.(IF:5.99)

(13) You Q, Li L, Xiong SQ, Yan YF, Li D, Yan NN, Chen HP, Liu YP*. Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia. Front Aging Neurosci. 2019 Apr 17;11:86.(IF:5.70)

(14) Liang Y, Wei G, Ning K, Li M, Zhang G, Luo L, Zhao G, Wei J, Liu Y, Dong L*, Chen S*. Increase in carbohydrate content and variation in microbiome are related to the drought tolerance of Codonopsis pilosula. Plant Physiol Biochem. 2021 Aug;165:19-35.(IF:5.44)

(15) 胡媛,吴蓓,易达,陈鸿平,杨放晴,王福,刘友平*.基于广泛靶向代谢组学技术与高通量测序技术探究广陈皮陈化机制[J].天然产物研究与开发,2022,34(04):553-562

(16) 申梦园,吴蓓,段涵琪,杨放晴,王福,陈鸿平,刘友平*.基于UPLC-Q-Orbitrap HRMS技术的乔林与叶林杜仲叶次生代谢产物比较研究[J].天然产物研究与开发,2022,34(08):1385-1399

(17) 杨悦,杨森,杨放晴,陈鸿平,陈林,刘友平*.熵权TOPSIS模型在竹叶花椒药材质量综合评价中的应用[J].必赢体育app下载,必赢体育学报,2022,45(01):5-10

(18) 申梦园,吴蓓,段涵琪,杨放晴,王福,陈鸿平,刘友平*.基于UPLC-Q-Orbitrap HRMS技术的乔林与叶林杜仲叶次生代谢产物比较研究[J].天然产物研究与开发,2022,34(08):1385-1399


2.授权发明专利

(1) 刘友平,陈鸿平,陈林,胡媛,郭换,闫珂薇,李峰庆,一种市售三七粉粉末部位来源的检测方法,2020.02.28, 中国,ZL201710757063.5

(2) 刘友平,陈鸿平,陈林,胡媛,刘珈羽,陈美君,伍清芳,一种白及品种及真伪的检测方法,2020.02.28, 中国,ZL201710757065.4

(3) 刘友平,陈鸿平,王福,张鑫,陈林,一种利用黄曲霉提高陈皮黄酮含量的方法, 2020.12.06,中国,ZL 201511016414.4

(4) 刘友平,陈鸿平,王福,张鑫,陈林,一种利用桔青霉提高陈皮黄酮含量的方法,2020.01.03,中国,ZL 201511016358.4

(5) 刘友平,陈鸿平,王福,张鑫,陈林,一种利用普通青霉提高陈皮黄酮含量的方法,2020.01.03,中国,ZL 201511010374.2

(6) 刘友平,陈鸿平,王福,张鑫,陈林,一种利用黑曲霉提高陈皮黄酮含量的方法,2019.10.25,中国,ZL201511010597.9

(7) 刘友平,陈鸿平,王福,张鑫,陈林,一种利用朱黄青霉提高陈皮黄酮含量的方法,2019.12.06,中国,ZL 201511010301.3

(8) 陈鸿平,刘友平,陈林,梁乙川,潘欢欢,胡媛,李雪莲,一种鉴别麸炒白术炮制火候的方法,2019.12.31,中国, ZL 201710620282.9

3.获奖

(1) “川产道地药材系统研究-川牛膝研究”,1998年获四川省科技进步三等奖

(2) “四逆散治疗功能性消化不良的临床实验研究”,2000年获四川省科技进步二等奖

(3) 远志质量标准规范化研究,2001年获四川省科学技术进步奖二等奖,排名第二 

(4) “川产道地及主流药材研究-乌梅质量标准规范化研究”,2005年获四川省科技进步三等奖,成都市科技进步二等奖

(5) 远志饮片炮制工艺及质量标准规范化研究,2008年获四川省科学技术进步奖二等奖,排名第二

(6) 中药品质理论创建与实践,2012年获四川省科学技术进步奖二等奖,排名第三

(7) 基于陈皮、青皮“一体二用”研究植物次生代谢产物动态变化与中药功效的相关性,2015年获四川省科学技术进步奖二等奖 ,成都市科学技术进步奖三等奖 ,2017年获华夏医学科技奖三等奖

(8) 白术炮制原理白术炮制原理及最佳炮制火候研究,2018年获四川省科学技术进步奖三等奖,排名第二

(9) 国家级中药学实验教学示范中心的构建与中药实验教学新体系的实践,2013年获四川省教学成果奖一等奖