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中药资源方向

裴瑾

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一、个人简介

裴瑾,博士,教授,博士生导师。西南特色中药资源国家重点实验室常务副主任,药学院/现代中药产业学院副院长。

国家中药种质资源库技术负责人,中药材标准化教育部重点实验室副主任。中华中医药学会中药鉴定专业委员会副会长,世界中医药学会联合会道地药材多维评价专业委员会秘书长,中国食品药品企业质量安全促进会区块链委员会副主任委员。四川省学术和技术带头人,四川省中医药学术和技术带头人,四川省中医药重点学科——药用植物学带头人,国家一流本科专业“中药资源与开发”负责人,规划教材《中药资源学》主编。

围绕中药资源可持续发展重大战略需求,从事中药资源保存与质量提升、道地药材品质形成机制和调控研究。构建我国中药种质低温保存技术体系,主持国家财政部、国家中医药管理局专项“中药种质资源库”、中药资源保障能力提升项目“中药资源战略性收集保存与保护”及四川省科技支撑计划“中药种质资源库建设关键技术研究及示范”等;主持“全国第四次中药资源普查四川2017-2019内业整理”,鉴定四川省46个县蜡叶标本13万份、药材3500余份、种苗2200余份;构建基于中药品质形成分子机制的“中药品质育种”研究策略,围绕红花、川牛膝、白芷等川产道地药材品质形成及新品种培育开展系统研究,主持国家自然科学基金“基于响应环境-调控合成功能基因解析红花有效成分积累的分子机制”“基于‘靶态’表型组与Stacking集成学习解析番红花 ‘叶-种球’表里关系构建种球质量预测模型”、四川省“十四五”育种攻关“突破性道地中药材育种材料和方法创新及新品种选育——红花”等,挖掘中药品质特性功能基因、开展中药新品种选育,并指导生产;致力于中药标准化研究,主持/参与ISO中医药国际标准“中药-西红花”“中药-红花”的制定及“泰国常用中药质量标准化”项目等。

Industrial Crops & Products、Phytomedicine、BMC Plant Biology、药学学报、中国中药杂志等发表论文两百余篇,包括一区TOP、高被引论文;副主编“十二五”“十三五”国家重大出版工程项目《中国药用植物志》(第三卷)、《中国临床药物大辞典》(饮片卷、中药成方制剂卷),《新编中国药材学》(第七卷),2021年获中国政府出版奖。


二、代表性成果

1、Tao Zhou, Xue Qiu, Li Zhao, Weijing Yang, Feiyan Wen, Qinghua Wu, Jie Yan, Binjie Xu, Jiang Chen, Yuntong Ma*, Jin Pei*.Optimal light intensity and quality increased the saffron daughter corm yield by inhibiting the degradation of reserves in mother corms during the reproductive stage[J]. Industrial Crops&Products, 2022,Volume176.(Q1,top)

2、Tiexin Zeng, Xiao Sun, Yujing Miao, ShengjiuGu, Lixia Tian, Yan Zheng, Yuan Jiang, XinkeZhang, Zhan Feng, Jin Pei*, Linfang Huang *.Integrating bioclimatic factors and secondary metabolism to predict the suitable producing area of plants with high specific metabolite content in a real-world environment - a case of Carthamus tinctorius L.[J]. Industrial Crops&Products, 2022,Volume177.(Q1,top)

3、Bin Xian, Rui Wang, Huajuan Jiang, Yongfeng Zhou, Jie Yan, Xulong Huang, Jiang Chen, Qinghua Wu, Chao Chen, Ziqing Xi, Chaoxiang Ren*, Jin Pei*. Comprehensive review of two groups of flavonoids in Carthamus tinctorius L.[J]. Biomed Pharmacother. 2022 Sep; 153:113462. (Q1)

4、Lanyu Zhou, Lijie Lu, Chao Chen, Tao Zhou, Qinghua Wu, Feiyan Wen, Jiang Chen, Hugh W.Pritchard, Cheng Peng, Jin Pei*and Jie Yan*. Comparative changes in sugars and lipids show evidence of a critical node for regeneration in safflower seeds during aging.[J]. Front. Plant Sci. 2022.13.(Q1,top)

5、Xu-Long Huang, Hua-Juan Jiang, Jin Pei*, Qing-Hua Wu*, Wei-Hua Wu*, Chao-Xiang Ren, Lan-Yu Zhou, Yong-Feng Zhou, Bin Xian, Chao Chen, Yan-Hang Yan, Li-Jie Lu, Yue Wang, Xing-Long Zhu. Study on the potential mechanism, therapeutic drugs and prescriptions of insomnia based on bioinformatics and molecular docking.[J]. Comput Biol Med., 2022 Aug; 106001. (Q1)

6、Xiaominting Song, Huanan Rao, Chuanjie Guo, Bo Yang, Yali Ren, Miao Wang, Yuzhi Li, Zhixing Cao*, Jin Pei*. Myricetin exhibit selective anti-lymphoma activity by targeting BTK and is effective via oral administration in vivo[J]. Phytomedicine, 2021 Dec; 93:153802.(Q2,top)

7、Song X, Tan L, Wang M, Ren C, Guo C, YangB, Ren Y, Cao Z, Li Y*, Pei J*. Myricetin: A review of the most recent research[J]. Biomedicine & Pharmacotherapy, 2021 Feb; 134:111017.(Q2,top,高被引)

8、Shengju Wang, Huajuan Jiang, Qianqian Liu, Yongfeng Zhou, Yanfen Cheng, Tao Zhou, Jinming Zhang, Yao He, Chaoxiang Ren*, JinPei*. A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical productio[J]. J Ethnopharmacol. 2022 May 23; 290:115114.(Q2)

9、Zhou Y, Niu M, Zhang D, Liu Z, Wu Q, Chen J, Zhang H, Zhang P*, Pei J*. Screening for Anti-Inflammation Quality Markers of Lianhua Qingwen Capsule Based on Network Pharmacology, UPLC, and Biological Activity[J]. Frontiers in Pharmacology, 2021 Jun 11; 12:648439.(Q2)

10、Chen J, Wang J, Wang R, Xian B, Ren C, Liu Q, Wu Q, Pei J*. Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in safflower (Carthamus tinctorius L.) under MeJA treatment[J]. BMC Plant Biol. 2020 Jul 29; 20(1):353.(Q2)

11、Chen J, Tang X, Ren C, Wei B, Wu Y, Wu Q, Pei J*. Full-length transcriptome sequences and the identification of putative genes for flavonoid biosynthesis in safflower[J]. BMC Genomics. 2018 Jul 24; 19(1):548.(Q2)

12、中药大品种康复新液系统创新及产业化关键技术研究应用,四川省科学技术进步一等奖,2016

13、中药品质理论创建与实践,四川省科学技术进步二等奖,2012

14、远志饮片炮制工艺及质量标准规范化研究,四川省科学技术进步二等奖,2008

15、活血温里复方中温里药提高活血药生物利用度的研究,四川省科学技术进步三等奖,2006

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