宋聚先
一、一般情况
宋聚先，中药学博士，博士后，杏林学者特聘教授，博士生导师，香港浸会大学访问教授。主持国家自然科学基金面上项目2项，参与香港研究资助局（RGC）项目2项，作为核心成员参与国家中医药传承创新团队等项目。在Autophagy，Acta Pharm Sin B，Journal of Neuroinflammation，Aging Cell 等国际高水平杂志发表30多篇学术论文，其中以第一和通讯作者身份发表SCI论文10余篇，获得美国及中国专利6项，担任Frontiers in Pharmacology 客座编委，Autophagy，Brain, Brain Behavior and Immunity等期刊审稿专家。主要研究方向为中医药调节细胞自噬治疗神经退行性疾病的分子机制研究及新药开发。
二、 代表性成果
1.代表性论文
1) Zhu Q?, Song J? (宋聚先), Chen JY?, Yuan Z, Liu L, Xie LM, Liao Q, Ye RD, Chen X, Yan Y, Tan J, Tan SH, Li M*, Lu JH*. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13(6):2701-2714. (IF:14.903; 1区Top)
2) Lin W, Li Z, Liang G, Zhou R, Zheng X, Tao R, Huo Q, Su C, Li M, Xu N, Tang C, Song JX* (宋聚先). TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation. J Neuroinflammation. 2023 Feb 2;20(1):21. (IF:9.587; 1区Top)
3) Jiang Y?, Lin Y?, Tan Y?, Shen X, Liao M, Wang H, Lu N, Han F, Xu N, Tang C*, Song J* (宋聚先), Tao R*. Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling. CNS Neurosci Ther. 2023 Mar;29(3):917-931. (IF:7.035; 1区Top)
4) Yang C, Su C, Iyaswamy A, Krishnamoorthi SK, Zhu Z, Yang S, Tong BC, Liu J, Sreenivasmurthy SG, Guan X, Kan Y, Wu AJ, Huang AS, Tan J, Cheung K, Song J* (宋聚先), Li M*. Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy. Acta Pharm Sin B. 2022 Apr;12(4):1707-1722. (IF:14.903; 1区Top)
5) Zhu Z, Liu LF, Su CF, Liu J, Tong BC, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Guan XJ, Kan YX, Xie WJ, Zhao CL, Cheung KH, Lu JH, Tan JQ, Zhang HJ, Song JX* (宋聚先), Li M*. Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy. Acta Pharmacol Sin. 2022 Oct;43(10):2511-2526. (IF:7.169; 1区Top)
6) Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK*, Song JX* (宋聚先), Li M*. Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. Phytomedicine. 2022 Feb;96:153887. (IF:6.656; 1区Top)
7) Zheng X, Lin W, Jiang Y, Lu K, Wei W, Huo Q, Cui S, Yang X, Li M, Xu N, Tang C*, Song JX* (宋聚先). Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB). Autophagy. 2021 Nov;17(11):3833-3847. (IF:13.391; 1区Top)
8) Song JX (宋聚先), Liu J, Jiang Y, Wang ZY, Li M*. Transcription factor EB: an emerging drug target for neurodegenerative disorders. Drug Discov Today. 2021 Jan;26(1):164-172. (IF:8.369; 2区)
9) Song JX (宋聚先), Malampati S, Zeng Y, Durairajan SSK, Yang CB, Tong BC, Iyaswamy A, Shang WB, Sreenivasmurthy SG, Zhu Z, Cheung KH, Lu JH, Tang C, Xu N, Li M. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2020 Feb;19(2):e13069. (IF:11.005; 1区Top)
10) Chen LL?, Wang YB?, Song JX? (宋聚先), Deng WK, Lu JH, Ma LL, Yang CB, Li M, Xue Y. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy. Autophagy. 2017;13(11):1969-1980. (IF:13.391; 1区Top)
11) Wang ZY, Liu JY, Yang CB, Malampati S, Huang YY, Li MX, Li M, Song JX* (宋聚先). Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review. Phytother Res. 2017 Aug;31(8):1119-1127. (IF:6.388; 2区)
12) Song JX (宋聚先), Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL*, Guo Z*, Li M*. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. (IF:13.391; 1区Top)
13) Song JX (宋聚先), Lu JH, Liu LF, Chen LL, Durairajan SS, Yue Z, Zhang HQ, Li M. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. (IF:13.391; 1区Top)
2.主持的主要项目
1) 国家自然科学基金面上项目：基于TFEB-HMGB1分子互作调控自噬与神经炎症探究电针改善阿尔茨海默病认知障碍的分子机制（82374571）
2) 国家自然科学基金面上项目：基于转录因子TFEB调控自噬溶酶体通路研究异鼠李素治疗帕金森病的疗效与分子机制（82074042）
3. 科研获奖
1) 中国生理学会中医药与脑稳态调控专业委员会第二届“中医脑科学大会”·2019年度优秀青年科学家