谢 欣
谢欣,医学博士/博士后,高级实验师,医学技术学院教职工第一党支部书记。主要研究方向为中药药效物质的分子作用机制和多维构效关系阐明、中药活性成分的结构修饰及中药新药发现。曾获必赢体育app下载,必赢体育四川省科技进步一等奖(第七完成人)。
先后主持国家博士后课题2项(面上项目1项及特别资助项目1项)、四川省科技厅项目1项、必赢体育app下载,必赢体育“杏林学者”课题3项;参与国家自然基金5项。相关成果发表在Chemical Communications; Advanced Synthesis & Catalysis; Synletter;The Chemical Record 等知名期刊,共计SCI收录15篇,其中以第一作者或通讯发表SCI论文10篇、其中IF大于5论文8篇,学科领域JCR一区论文3篇、ESI高被引论文1篇。获得国家授权发明专利5项;参编专著5部。
※ 近年来主要代表性论文
[1] Xie, X.; Xiong, S.-S.; Li, X.; Huang, H.; Wu, F.-B.; Shen, P.-F.; Cheng Peng, He, G.*; Han, B.* Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors. Organic Chemistry Frontiers 2021,8, 1836-1843. IF 5.155
[2]Xie, X.; Xiang, L.; Peng, C.*; Han, B*. Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry. Chemical Record 2019, 19(11), 2209. IF: 6.163
[3]Xie, X.; Huang, W.; Peng, C.*; Han, B.* Organocatalytic Asymmetric Synthesis of Six-Membered Carbocycle-Based Spiro Compounds. Advanced Synthesis & Catalysis 2018, 360, 194-228. IF 5.646
[4] Xie, X.; Peng, C.*; He, G.; Leng, H.-J.; Wang, B.; Huang, W.*; Han, B.* Asymmetric synthesis of a structurally and stereochemically complex spirooxindole pyran scaffold through an organocatalytic multicomponent cascade reaction. Chemical Communications 2012, 48(85): 10487. IF: 5.996
[5]Xie, X.; Peng C. *; Leng H. J.; Wang B.; Tang Z. W.; Huang W*. Asymmetric synthesis of oxa-spirocyclic indanones with structural complexity via an organocatalytic Michael–Henry–Acetalization cascade. Synlett 2014, 25, 143-147. IF 2.419
[6]Mu, J.?; Xie, X.?; Xiong, S.-S.; Zhang, Y.-H.; Wang, Y.-T.; Zhao, Q.; Zhu H.-P.; Huang, W.*; He, G.* Discovery of spirooxindole–ferrocene hybrids as novel MDM2 inhibitors. Chinese Chemical Letters 2021, 32, 1897-1901. IF 4.632
[7]Han, B.?; Xie, X.?; Huang, W.; Li, X.; Yang, L.; Peng, C.* Organocatalytic Morita-Baylis-Hillman/Michael/Acetalization Cascade: Procedure-Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans. Advanced Synthesis & Catalysis 2014, 356(17), 3676. IF: 5.851
[8]Tang, Z. W.?; Xie, X.?; Huang, W.; Leng, H. J.; Wang, B.; Han, B.*; Peng, C.* Exploring the Antibacterial Target of the Main Constituent of Pogostemon cablin by using Molecular Docking and Network Analysis. Latin American Journal of Pharmacy 2016, 35, 502-509. IF 0.298
※ 近年来主出版专著
(1)中国临床药物大词典. 中药饮片卷. 中国医药科技出版社. 常务编委. 2018
(2)中国临床药物大词典. 成方制剂卷. 中国医药科技出版社. 常务编委. 2018
(3)有毒中药附子、川乌、草乌的安全性评价与应用. 四川科学技术出版社. 编委. 2014
(4)中华道地药材. 中国中医药出版社. 编委. 2013