余志银
个人简介
余志银，天然产物发现和生物合成研究课题组组长，必赢体育app下载,必赢体育中医药创新研究院/本草基因组学研究院副研究员，硕士生导师。2020年，博士毕业于东北农业大学，之后在中国科学院昆明植物研究所黄胜雄研究员团队从事博士后研究。以第一作者在Nat Commun、Angew Chem Int Ed、Front Chem、Front Microbiol、J Agric Food Chem等期刊发表多篇论文。
邮箱：zhiyinyu@cdutcm.edu.cn
研究方向
围绕药用植物及相关微生物资源中新颖结构天然产物的发现、生物合成和生物活性展开研究：（1）基因组导向的微生物中新颖结构天然产物的发现和生物合成；（2）药用植物中重要活性分子的生物合成途径解析及酶催化机制研究；（3）植物环肽靶向G蛋白偶联受体（GPCR）相关药物发现。
主持科研项目
国家自然科学青年基金, 吡啶生物碱卡诺霉素的生物合成及吡啶环形成的机制研究（22107014），2022/01-2024/12，30万元，在研，主持。
必赢体育app下载,必赢体育，“杏林学者”学科人才科研提升计划博士后专项，内皮素转化酶抑制剂卡诺霉素的生物合成及构效关系研究（BSH2021034），2021/06-2024/12，12万元，在研，主持。
代表性论文（?为共同第一作者，*为通讯作者）
1. Pei Zhao, Zhiyin Yu, Jian-Ping Huang, Li Wang, Sheng-Xiong Huang*, Jing Yang*. Four unreported aporphine alkaloids with antifungal activities from Artabotrys hexapetalus. Fitoterapia, 2024,174,105868.
2. Zhiyin Yu?, Jian-Ping Huang?, Jing Yang?, Chongxi Liu, Yijun Yan, Li Wang, Junwei Zhao, Yin Chen, Wensheng Xiang*, ang Sheng-Xiong Huang*. Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors. Nature Communications, 2023, 14: 209.
3. Xiaotao Tuo?, Zhiyin Yu?, Junheng Li, Yuxin Qi, Guoqing Peng, Sheng-Xiong Huang, Xueshuang Huang, Jian-Ping Huang*. Characterization of two putative norlaudanosoline methyltransferases from Aristolochia debilis. Journal of Plant Physiology, 2023, 285: 153983.
4. Li Wang, Zhi Zhou, Jian-Ping Huang, Liang Zhang, Xiaotao Tuo, Zhiyin Yu, Sheng-Xiong Huang, Yang Liu*, Jing Yang*. Strepyrrolins A–E, five pyrrole–sesquiterpene hybrids from Streptomyces sp. KIB 015, revealing a new formation logic of pyrroles by isotope labeling. Organic Chemistry Frontiers, 2023,10 (4), 880-889.
5. Yijun Yan?, Zhiyin Yu?, Wei Zhong?, Xiaodong Hou, Qiaoqiao Tao, Minhang Cao, Li Wang, Xiaofeng Cai, Yijian Rao, Sheng-Xiong Huang*. Characterization of Multifunctional and Non-stereoselective Oxidoreductase RubE7/IstO, Expanding the Functional Diversity of the Flavoenzyme Superfamily. Angewandte Chemie-International Edition. 2022, 61, e202200189.
6. Chuanyu Han?, Zhiyin Yu?, Yuting Zhang, Zhiyan Wang, Junwei Zhao, Sheng-Xiong Huang, Zhonghua Ma, Ziyue Wen, Chongxi Liu*, Wensheng Xiang*. Discovery of Frenolicin B as Potential Agrochemical Fungicide for Controlling Fusarium Head Blight on Wheat. Journal of Agricultural and Food Chemistry, 2021, 69, 2108-2117.
7. Li Wang?, Zhiyin Yu?, Xiaowei Guo, Jian-Ping Huang, Yijun Yan, Sheng-Xiong Huang*, and Jing Yang*. Bisaspochalasins D and E: two heterocycle-fused cytochalasan homodimers from an endophytic Aspergillus flavipes. The Journal of Organic Chemistry, 2021, 86(16): 11198-11205.
8. Zhiyin Yu, Hao Jiang, Li Wang, Feng-Xian Yang, Jian-Ping Huang, Chongxi Liu, Xiaowei Guo, Wensheng Xiang* and Sheng-Xiong Huang*. Dimeric Pimprinine Alkaloids from Soil-Derived Streptomyces sp. NEAU-C99. Frontiers in Chemistry, 2020, 8, 95.
9. Zhiyin Yu?, Chuanyu Han?, Bing Yu, Junwei Zhao, Yijun Yan, Shengxiong Huang, Chongxi Liu*, and Wensheng Xiang*. Taxonomic Characterization, and Secondary Metabolite Analysis of Streptomyces triticiradicis sp. nov.: A Novel Actinomycete with Antifungal Activity. Microorganisms, 2020, 8, 77.
10. Zhiyan Wang?, Zhiyin Yu?, Junwei Zhao?, Xiaoxin Zhuang, Peng Cao, Xiaowei Guo, Chongxi Liu* and Wensheng Xiang*. Community Composition, Antifungal Activity and Chemical Analyses of Ant-Derived Actinobacteria. Frontiers in Microbiology, 2020, 11, 201.
11. Chuanyu Han?, Zhiyin Yu?, Junwei Zhao?, Haoran Shi, Jiangmeihui Hu, Bing Yu, Jia Song, Yue Shen, Wensheng Xiang* and Xiangjing Wang*. Streptomyces triticagri sp. nov. and Streptomyces triticirhizae sp. nov., two novel Actinobacteria isolated from the rhizosphere soil of wheat (Triticum aestivum L.). International Journal of Systematic and Evolutionary Microbiology, 2020, 70, 126-138.
12. Yijun Yan, Jing Yang, Li Wang, Dongdong Xu, Zhiyin Yu, Xiaowei Guo, Geoff P. Horsman, Shuangjun Lin, Meifeng Tao and Sheng-Xiong Huang. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase. Chemical Science, 2020, 11, 3959–3954。
13. Feng-Xian Yang, Jian-Ping Huang, Zhixiang Liu, Zhiyan Wang, Jing Yang, Jun Tang, Zhiyin Yu, Yijun Yan, Guoyin Kai* and Sheng-Xiong Huang*. Benwamycins A?G, Trialkyl-Substituted Benzene Derivatives from a Soil-Derived Streptomyces[J]. Journal of Natural Products, 2020, 83, 111-117. (二区期刊, IF=5.1)
14. Xiaowei Guo, Jidong Wang, Can Su, Chongxi Liu, Xiaoyan Ma, Zhiyin Yu, Jiansong Li, Xiangjing Wang, Wensheng Xiang* and Sheng-Xiong Huang*. A Unique Spiro-β-Triazinedione-γ-Hydantoin Type Alkaloid with Antiviral Activity against Tobacco Mosaic Virus from Streptomyces gamaensis [J]. Organic Chemistry Frontiers, 2019, 6(18): 3215-3219.
15. Zhiyin Yu, Li Wang, Jing Yang, Fan Zhang, Yun Sun, Mingming Yu, Yijun Yan, Ya-Tuan Ma*, Sheng-Xiong Huang*. A New Antifungal Macrolide from Streptomyces sp. KIB-H869 and Structure Revision of Halichomycin. Tetrahedron Letters. 2016, 57, 1375-1378.
16. Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo. Geoffrey P. Horsman& Sheng-Xiong Huang. Non-enzymatic Pyridine Ring Formation in the Biosynthesis of the Rubrolone Tropolone Alkaloids. Nature Communications. 2016, 7: 13083.