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个人简介：

丛朝彤，本草基因组学研究院副院长，中药分子药理学课题组组长，研究员，博士/硕士研究生导师。2021年博士毕业于复旦大学药学院，曾获选上海市“超级博士后”激励计划和中国博士后创新人才支持计划，主持国自然青年基金项目和博士后面上项目。主要研究方向为GPCR结构药理学，在解决B1类GPCR多肽药物副作用严重、小分子药物开发困难和受体激活机制不明确等问题方面做出多项原创性工作，以第一、共一或通讯作者在国际上发表多篇高影响力论文，包括PNAS（2021, 2022, 2023）、Nature Communications（2020, 2021, 2022）、Cell Discovery (2024)等著名期刊。

研究方向：主要研究方向为GPCR结构药理学，关注基于GPCR靶点的中药开发。

邮箱：congzt@cdutcm.edu.cn

代表性成果：

1.       Zhaotong Cong^#, Fenghui Zhao^#, Yang Li, Gan Luo, et al. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G_s proteins. Cell Discovery (2024) 10(1):18. (IF: 38.079)

2.       Yang Li^#, Qingtong Zhou, Antao Dai, Fenghui Zhao, Rulve Chang, Tianlei Ying, Beili Wu, Dehua Yang*, Mingwei Wang*, Zhaotong Cong*^#. Structural analysis of the dual agonism at GLP-1R and GCGR. PNAS (2023) 120 (33) e2303696120. (IF: 11.205)

3.       Zhaotong Cong^#, Yi-Lynn Liang^#, Qingtong Zhou^#, Sanaz Darbalaei, et al. Structural perspective of class B1 GPCR signaling, Trends in Pharmacological Sciences (2022), 43(4): 321-334. (IF: 17.638)

4.       Zhaotong Cong^#, Qingtong Zhou^#, Yang Li, et al. Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24. PNAS (2022) 119 (20) e2200155119. (IF: 11.205)

5.       Zhaotong Cong^#, Li-Nan Chen^#, Honglei Ma^#, Qingtong Zhou^#, Xinyu Zou et al. Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nature Communications (2021) 12:3763. (IF: 17.694)

6.       Zhaotong Cong^#, Fulai Zhou^#, Chao Zhang^#, Xinyu Zou^#, Huibing Zhang et al. Constitutive signal bias mediated by the human GHRHR splice variant 1. PNAS (2021) 118(40): e2106606118. (IF: 11.205)

7.       Fenghui Zhao^#, Qingtong Zhou^#, Zhaotong Cong^#, Kaini Hang^# et al, Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nature Communications (2022) 13:1057. (IF: 17.694)

8.       Fulai Zhou^#, Huibing Zhang^#, Zhaotong Cong^#, Li-Hua Zhao^# et al, Structural basis for activation of the growth hormone-releasing hormone receptor. Nature Communications (2020) 11:5205. (IF: 17.694)

9.        Zhaotong Cong, Yanbin Shi, Yang Wang, et al. A novel controlled drug delivery system based on alginate hydrogel/chitosan micelle composites. International Journal of Biological Macromolecules, 107PA (2018) 855-864. (IF: 8.025)